Finding the Best Topics for a Proposal Essay

Finding the Best Topics for a Proposal Essay Topics for a Proposal Essay and Topics for a Proposal Essay - The Perfect Combination Keep in mind, proposal essays serve a purpose beyond academia. They are common in business and science classes and professions, but are also useful for a number of different disciplines. Because they are a type of argumentative essay, you want to be sure the essay is worthy of an argument. Both of the essays are alike in their tone and the usage of irony. The most powerfully ironic facet of this essay is quite obvious. For the reason why that evaluation essay is basically targeted at analyzing any topic article or book a fantastic number of students confuse this form of paper with a review. Adults who went into teaching only to teach, are going to be able to do that. The Nuiances of Topics for a Proposal Essay Management knows that should they don't locate the upcoming new thing, their company will decline. Most importantly, it must be ensured they are not once again seeking the military and financial position of a superpower. Developing and innovating new products and services which have the ability to earn excess returns is hard. As a consequence the whole period of above average returns for any specific product or service have a tendency to be far shorter than in different industries. It's not possible to imagine a significant proposal for eating children. If you're unsure how to cook a youngster, don't worry. Together w ith free public pre-K, toddlers ought to be taught and trained on how best to use their guns. Additional forcing parents to obtain guns for their unborn children would create a lot bigger demand in the firearm market. The Unexposed Secret of Topics for a Proposal Essay In Tokyo, in order to obtain a vehicle, you have to have a dedicated parking space, and that costs more than the vehicle. So it's really expensive to have a whole vehicle. Better yet, the author calculates just how much a youngster should weigh to serve the most quantity of guests. So we are in need of access to cars. What You Must Know About Topics for a Proposal Essay API Gateway provides stages to enable you to have multiple deployed APIs below the identical gateway. Making the required equipment is merely the very first half of the equation. Access is wholly free so check the very best samples at this time. The entire article is well worth a read for a very good overview of where things stand today. Then you can pick which side of the argument you wish to tackle. All you will need is the proper topic. Irrespective of the political results of the Brexit debacle, the depressing truth is that the folks will continue being divided. Any lunar colonization effort is going to have the advantage of lots of expensively acquired experience. Therefore, we have to strike at the heart of a robber baron's motivations. The secret is to identify all the components needed to earn colonization feasible then seed ventures to develop every one of those components. It's somewhat hard to estimate what type of investment lunar colonization might require. The goal isn't to rationalize the tax system, though there is far more progress to be made in that region. In such a dire time where we have an expanding federal deficit, growing infrastructure problems which should be covered, and increasing unease about our function on earth economy, we really should make some hard choices about what's in the very best interest of our nation for a whole. Initially it may appear tempting to file for ownership based on the institution of a lunar presence and then and sell lunar property. Secondly, any effort to file for ownership will probably provoke a government response either in the shape of legislation or competing lunar programs. Finally, you're trying to persuade the reader your proposal is not just viable, but one worth pursuing. The concept people can present a notion in a very clear and precise manner isn't the insult. In a terse fashion, it touches on a lot of the vices of the human condition. There are some important moments of sa tirical success that ought to be mentioned. It is possible to probably already anticipate the benefits I am going to describe next. So, it must be clear what must be done in order to reverse this trend. In addition, the fertility rates of non-white individuals will correspondingly plummet. It appears that there is a negative correlation between fertility prices and income. It's going be far more enjoyable in case you have some passion for the subject issue. Of course it went way beyond the very first few weeks. For instance, how to make the absolute most out of your Saturday afternoon isn't a very good topic (although all of us know it's sleeping in and watching cartoons). You only have to receive 26 right. The Truth About Topics for a Proposal Essay So, together with a social security number, every baby should secure the most current in gun technology. Nobody should have an ammunition magazine that holds over five rounds. Let's return and have a look at the Clinton Whi te House. Therefore, we are in need of a sensible man to produce a low-cost, effective procedure to lessen the variety of school shootings.

Topic For Research Paper in It - What You Need to Do to Start Writing Your Topic For Research Paper

Topic For Research Paper in It - What You Need to Do to Start Writing Your Topic For Research PaperYou have just finished your topic for research paper in it. The last thing you want to do is to start researching, especially if you are not familiar with the subject at all. So, if you are starting a topic for research paper, here are some helpful hints that will help you get through the process of starting a topic for research paper.First, find out what your topic is. You can either do this from a class, online, or a book or anything that you can find out. Since you do not know what you are writing about, this is a good time to not only find out the topic but also the specific purpose of the research you are going to do.Next, select a topic. Sometimes, I like to write about a topic that I really want to read. However, if you are the type of person who likes to do research on interesting subjects, it might be a good idea to stay away from such topics. But if you feel adventurous, do wh at you want.Next, decide on a theme for your topic. Themes will give you the idea of what kind of research you want to do. When choosing a theme, be sure to take into consideration the environment you are writing in.Lastly, you have to write the summary. Summaries are very important to make a topic for research paper in it easier to read. They will also help you show the end of your research in the future.Lastly, you have to fill in the blanks. In most cases, the questions for the research paper you will write will include the research you did, the subject of the topic, and the main objective of the research. This part of the paper is very important, since you are writing about yourself. This part of the paper will help you further explain your research.These are some things you need to do in order to get started on your topic for research paper in it. I hope you found these tips useful.

Benefits of Using Method Essay Writing

Benefits of Using Method Essay WritingIf you have not yet heard of the method essay writing, then it is time you did. There are several benefits to using this method that make it the best for you. In this article I will tell you about these benefits and the one that are most important to you.The first benefit that you will get out of using this method is that you will be able to improve your grades at school. All of your essays are now given grades by professors. This means that your grades are now affected by the quality of your essays. The better your essay is the higher the grade you will get. With this method you will be able to improve your grade all the time.The second benefit that you will need to have is that you will be able to write things in a more organized way. With the way we write right now we tend to get confused and many of our sentences end up being missing words. This problem can make it difficult for you to know what to write and how to structure your essay. With this method you will be able to use those filler words that you often write so that you will not need to write them on your paper anymore.The third benefit that you will need to have is that you will be able to write more concisely. Often, when we write we end up with paragraphs that are much longer than they should be. This means that the words are sometimes chopped off and many of the sentences can even be misplaced. With this method you will be able to use shorter sentences that will be much more concise.The fourth benefit that you will need to have is that you will be able to write faster. With the way we write today we are often distracted and it takes us longer to finish an essay. With this method you will be able to complete many of your essays faster. You will also be able to quickly type up your essay so that you will not have to stop and look up words.The fifth benefit that you will need to have is that you will be able to write better. This means that you will be able to get better grades all the time. This will mean that you will be able to write your paper faster and to make it more appealing to the professor. All of this will mean that you will be able to be competitive in the class.The above are just some of the benefits that you will get out of using this method. There are others that I will be writing about soon.

Sample of Reflective Essay About Movie

Sample of Reflective Essay About MovieIf you have ever written a reflective essay, you will most likely find that reflecting on something that made you laugh or made you sad is an easy way to start a reflection about a movie. I'm sure you probably know what the reasons are for laughing or for being sad. Reflecting on an essay can be very easy because it's all reflective. We all know that everything happens for a reason.The important part to remember is that reflection is always an important part of writing. You can tell an important point through another. In this article I'm going to give you some simple suggestions to help you write a reflective essay about a movie. Remember, you are writing an essay about a movie and this is reflective. So, what should you reflect on?The first thing that you might want to reflect on is why you chose to see the movie. Don't worry about what the movie is about or who the people are in the movie. Reflect on what it is about the movie that made you wan t to see it. If it's just the acting, you may not want to think about what it is about the acting.Next, consider what the movie has to offer. As we mentioned before, if the acting is your focus, you can reflect on what the movie offers you. If the movie is just the acting, you can also reflect on what the movie has to offer in other ways such as education, entertainment, or any other way that you choose.Finally, reflect on what you like about the movie. Many people enjoy listening to music or watching an entertaining movie. You don't have to have seen the movie in order to love it. If the movie is just the acting, you may just enjoy watching someone else experience something else.Tsample of reflective essay about movie Reflecting on your essay can be very difficult, but remember that you are writing an essay about a movie. If it's reflective, it will stand out from the rest of the essays that you find. Keep in mind that there are many essays on the Internet.To reflect on your essay , you need to take some time to really think about what you're doing. It's better to take a little more time than you think you will need to. Just put some thought into it and write it down and then move on to the next one. It can be very helpful.

Why Migraines Occur Essay Example

Why Migraines Occur Essay Migraine tends to affect more than 300 million people from across the world.   For many, the condition is more than a headache and is characterized by several distinctive symptom phases.   The condition is characterized by severe, debilitating and disabling headache that often needs no description.   The people suffering from migraine also had several other problems including photophobia, burning, nausea, vomiting, visual disturbances, altitude sickness, etc.   Migraine may have several other implications.   About 17 billion dollars a year is lost due to lost work, disabilities and healthcare expenditure owing due to headache.   Through historical records, it has been suggested that the disorder has affected man for more than 7000 years.   However, medicine still continues not to identify the cause and a treatment that could help cure the disorder.   Many people do not even approach the doctor to get the disorder treated as they feel that medical treatment can do litt le or no help.   Earlier, scientific research proved that the disorder was a vascular condition, but today scientists have identified that it is more of a neurological condition that develops primarily from pathology in the brain stem cells.   The nerve cell malfunction tends to sweep across other parts of the brain.   Today, the exact cause of migraine is still unknown, but scientists are developing several new forms of treatment for the condition including gene therapy (after considering the genetic basis of the disease), molecular biology and imaging of the brain.   This would enable to get back to normal activities faster (Dodick, 2008, Kantor, 2006). The neuro-vascular model which has been implicated for the cause of migraine includes vascular and neurological factors.   Another model frequently being considered is the Convergence Hypothesis that tries to associate the clinical symptoms with the pathophysiology of migraine.   According to this model, migraine is considered to be an event with a beginning, a mid and an end.   A symptom-based diagnostic approach would consider migraine during the peak stages.   With the convergence model, the entire process would be looked up on including the prodromal, the aura and the end phases.   Using the convergence model, the events can be drawn as a curve when charted against time (Curtis P. Schreiber, 2005). We will write a custom essay sample on Why Migraines Occur specifically for you for only $16.38 $13.9/page Order now We will write a custom essay sample on Why Migraines Occur specifically for you FOR ONLY $16.38 $13.9/page Hire Writer We will write a custom essay sample on Why Migraines Occur specifically for you FOR ONLY $16.38 $13.9/page Hire Writer Body Migraine is a chronic medical disorder characterized by disabling headache, nausea, vomiting and photophobia.   In many people, the throbbing headache may be experienced on one-side of the face. The condition usually occurs in 11 % of the people in the US.   Migraine is more common in people with a family risk of the condition. It occurs anywhere between the ages of 10 to 46 years, and is more common in women compared to men.   In women, the condition may even occur beyond till the age of 55 years.   During the period of pregnancy, the number of migranous attacks usually reduces.   During the 1980’s scientists found that migraine develop due to a disorder in the blood vessels that supply the brain.   However, today it is clear that the condition develops due changes in the brain, nerve pathways and the chemicals present in the brain (Dodick, 2008, Kantor, 2006). From one individual to another, the frequency, duration, severity and aggravating factors of migraine would differ significantly.   On an average, people suffer from migraine, one or two days every month.   About 10 % of the population gets the disorder every week and 20 % get the attacks every 2 to 3 days, and about 14 % develop a serious version of the disease, in which the symptoms are seen every alternate day (Dodick, 2008, Kantor, 2006). Several events may trigger or aggravate attacks of migraine including alcohol consumption, dehydration, physical stress, exertion, menstruation, emotional stress, anxiety, seasonal, climatic or weather changes, allergy, bright lights, loud noises, florescent lights, sleep alterations, missing meals, tension headache, use of birth control pills, lack of sleep, staying at higher altitudes, hunger, certain foods, smoking, tobacco consumption, etc.   Some of the foods that can trigger migraine attacks include foods containing tyramine, monosodium glutamate or nitrates. Some of the foods that contain tyramine include red wine, cheese, smoked fish, liver of chicken, bens, figs, etc, and foods that contain nitrate include hot dogs, salami and bacon.   Other foods that can also trigger migraine attacks include citrus fruits, bananas, avocados, onions, dairy products, chocolates, pickles, nuts, peanut butter, fermented products, etc.   The ancient Greeks were the ones to coin the word m igraine from ‘megrim’ meaning hemicrania or one-sided headache.   Galen considered migraine to be a painful disorder that affected one half of the head.   The Greeks considered to be caused due to descent of the vapors from the liver to the brain.   Later, in the 17th century, blood flow defects were considered to be the main cause for migraine rather than humors.   From the 17th century to the 1980’s, the vascular theory proved to be responsible cause for migraine.   Wolff from the Presbyterian hospital New York considered that migraine was caused due to dilatation and expansion of the blood vessels present in the brain.   Once the expansion of the blood vessels occurs, the pain-signaling neurons of the brain get activated, leading to a headache.   Before the headache actually occurs, there is a drop in the blood supply to the brain causing constriction of the blood vessels.   However, newer research work conducted in the field of migraine demons trates that the disorder is caused not due to vascular alterations but due to neurological changes.   Earlier it was thought that vascular flow of the blood in the brain had increased something like 3-fold times.   In fact, latest scientific evidence clearly suggests that just before the migraine attack, the cerebral blood flow is either normal or drops down a bit (Dodick, 2008, Kantor, 2006). The aura that occurs before the migraine attacks was a serious clue to the scientists that the disorder had a neurological basis.   The aura can be seen in two conditions, one in migraine as a preceding symptom and the other in epileptic seizures as a part of the sensory visual hallucinations.   The individual in migraine would be able to see stars, bright lights, sparks, lightning bolts, geometric designs, etc.   In some people weakness, speech impairments and tingling sensations develop.   In some people, the visual aura may not appear and all, but in other it may even occur during the entire headache phase.   Today, scientists have identified the exact mechanism of this aura.   A wave of intense nerve activity (cortical spreading depression) spreads throughout the cortex especially the areas of vision.   Following the hyperexcitability, there is a phase of neural inhibition.   During the phase of intense neuronal activity, there is active firing and a lot of energy is required.   Following the intense neuronal firing, the nerve cells require less quantity of blood.   The neuronal firing spreads at the rate of 2 to 3 millimeters every minute, and this is just the exact rate at which aura develops.   Besides affecting vision, the intense neuronal activity would also affect sensory and motor signals (Dodick, 2008 NINDS, 2008). Studies have clearly shown that genetic factors play a very important role in the development of migraine.   The genetic susceptibility of migraine is similar to other disorders such as diabetes, hypertension, etc.   In identical twins, the other twin is at a higher risk of developing the disorder, when one twin actually suffers from it.   However, non-genetic or environmental factors play an important role in the development of migraine.   Genetic factors may increase the excitability of the neurons, leading to a disturbance in the ion transportation system.   Several other disorders may also be as a cause of ion transportation defects including seizures and cardiac arrhythmias (Dodick, 2008 NINDS, 2008). The exact way in which the spreading cortical depression of neurons causes’ headache is not understood clearly, but scientists feel that the trigeminal nerve may be involved.   The manner in which the trigeminal nerve causes pain sensation is not understood clearly.   When the intense cortical depression spreads, it causes chemical changes in the neurotransmitters leading the trigeminal nerve to transmit pain sensations.   The spreading depression can also activate the trigeminal nerves in the subcortical regions leading to headache.   The mechanism of aura may operate in both, people suffering from migraine with or without aura.   However, in people who do not suffer from aura may develop other symptoms including tiredness, weakness or difficulty concentrating.   Besides, involvement of the cortical and the subcortical regions in migraine, the brain stem (an ancient part of the brain) may be responsible for migraine pain.   The brain stem contains three groups o f nuclei that can play an important role in migraine.   The nuclei would inhibit the firing of the trigeminal nerve, thus causing the trigeminal neuron to fire without any pain signal.   There would be an incoming pain signal although actually there are no stimuli.   Besides, involvement of the trigeminal nerve from the brain stem, other sensory nerves including those that control visual functions may also be affected, resulting in false sensory incoming signals causing visual field disturbances (Dodick, 2008 NINDS, 2008). During an attack of migraine several processes tend to occur.   Certain triggering factors mentioned may stimulate the release of peptides such as substance P, Calcitonin Gene-related peptide, etc.  Ã‚   They tend to dilate blood vessels and cause inflammation which results in over-excitation of the trigeminal nerve.   The brain would not be affected with the headache, but the blood vessels and the meninges would be involved.   Auras occur as a result of blood flow changes (Daniel Kantor, 2007). Certain migraine headaches occur due to abnormalities in the calcium channels and also the magnesium, potassium and sodium channels.   Calcium channels present control the release of the neurotransmitter serotonin.   This neurotransmitter can play an important role in the development of migraine.   Besides, abnormalities in the levels of other neurotransmitters such as dopamine and stress hormones can result in migraine.   Dopamine could act as a stimulant of migraine and in certain individuals with genetic characteristics, higher levels of dopamine can result in nerve cell excitation.   Several prodromal symptoms such as mood changes, drowsiness and yawning are closely associated with dopamine disturbances.   The calcium channels play a vital role in the development of the cortical spreading depression (which is the cause of the migraine symptoms).   In people who suffer from migraine, magnesium deficiencies have been found.   During a migraine attack, a drop in the magnesium levels has been observed.   Once the levels of magnesium levels are low, the nerve cells become highly unstable and tend to misfire.   This could be responsible for the aura that develops.   Magnesium has been strongly associated with the calcium channels in the body.   Certain inherent deficiencies in the calcium channel systems may be present in people who develop migraine. Individuals with familial hemiplegic migraine have mutation of the gene that expresses for calcium channel systems.   Nitric Oxide has also been associated with migraine and other headaches.   Over-excitation of the nerve cells can result in the production of nitric oxide.   A rise in the nitric oxide in the blood vessels may stimulate several nerves in the brain and cause the development of pain.   Hormone fluctuations can also play a role in the development of migraine.   The changes in several hormones especially estrogen can be responsible for migraine development.   If the hor mone levels are high, low or normal for long, the migraine process would not be activated.   Hormonal fluctuations are more likely to cause migraine.   This is because fluctuations impact the serotonin and other neurotransmitter levels (Daniel Kantor, 2007). Conclusion Today, a lot of research has been identified which potentially helps to better under the migraine process.   Migraine is more of a neuro-vascular condition rather than a vascular condition earlier thought.   Currently, there are no specific drugs to treat migraine, and most of them are other groups of drugs that are utilized to treat other conditions.   Usually, ergotamine preparations, painkillers, NSAIDS, etc are given which works partially.   Hence, it has been clearly observed that they can work only in half the number of migraine patients.   Several groups of antihypertensive drugs, anti-seizure drugs, calcium channel blockers and antidepressants may work by normalizing the membrane potential thus helping to curb the rapidly-spreading cortical nerve depression.   They would work in patients who develop migraine with or without aura.   These groups of drugs would work by prevent channels present on the nerve membrane from opening up, thus helping to control calcium movement.   In this way, the nerve membrane would be stabilized.   Individuals also need to adopt a diet that can effectively help avoiding headache provoking foods and substances such as cheese, tobacco, alcohol, etc.   Blood glucose and blood pressure should be monitored and kept under control.   Better sleep hygiene and exercising patterns need to be ensured.   Stress needs to be handled in more appropriate fashions (Curtis P. Schreiber, 2005, Dodick, 2008 Mayo, 2007). Works Cited Curtis P. Schreiber. â€Å"The Pathophysiology of Migraine.† Clinics in Family Practice 7.3 (2005). Daniel Kantoor. â€Å"Migraine headaches – Highlights, FDA Warning: Serotonin Syndrome.† 2007. ADAM. 29 Nov 2008. http://www.mdconsult.com/das/patient/body/111946799-8/777861931/10041/9399.html Daniel Kantor. â€Å"Migraine.† Medical Encyclopedia. 2006. Medline Plus. 16 Nov 2008. http://www.nlm.nih.gov/medlineplus/ency/article/000709.htm David W. Dodick and J. Jay Gargus . â€Å"Why Migraines Strike.† Scientific American. (July, 2008). http://www.sciam.com/article.cfm?id=why-migraines-strike Mayo Clinic. â€Å"Migraine.† 2007. Mayo Clinic. 16 Nov 2008. http://www.mayoclinic.com/print/migraine-headache/DS00120/DSECTION=allMETHOD=print NINDS. â€Å"Headache: Hope through Research.† 2008. NINDS. 16 Nov 2008. http://www.ninds.nih.gov/disorders/headache/detail_headache.htm Why Migraines Occur Essay Example Why Migraines Occur Essay Migraine tends to affect more than 300 million people from across the world.   For many, the condition is more than a headache and is characterized by several distinctive symptom phases.   The condition is characterized by severe, debilitating and disabling headache that often needs no description.   The people suffering from migraine also had several other problems including photophobia, burning, nausea, vomiting, visual disturbances, altitude sickness, etc.   Migraine may have several other implications.   About 17 billion dollars a year is lost due to lost work, disabilities and healthcare expenditure owing due to headache.   Through historical records, it has been suggested that the disorder has affected man for more than 7000 years.   However, medicine still continues not to identify the cause and a treatment that could help cure the disorder.   Many people do not even approach the doctor to get the disorder treated as they feel that medical treatment can do litt le or no help.   Earlier, scientific research proved that the disorder was a vascular condition, but today scientists have identified that it is more of a neurological condition that develops primarily from pathology in the brain stem cells.   The nerve cell malfunction tends to sweep across other parts of the brain.   Today, the exact cause of migraine is still unknown, but scientists are developing several new forms of treatment for the condition including gene therapy (after considering the genetic basis of the disease), molecular biology and imaging of the brain.   This would enable to get back to normal activities faster (Dodick, 2008, Kantor, 2006). The neuro-vascular model which has been implicated for the cause of migraine includes vascular and neurological factors.   Another model frequently being considered is the Convergence Hypothesis that tries to associate the clinical symptoms with the pathophysiology of migraine.   According to this model, migraine is considered to be an event with a beginning, a mid and an end.   A symptom-based diagnostic approach would consider migraine during the peak stages.   With the convergence model, the entire process would be looked up on including the prodromal, the aura and the end phases.   Using the convergence model, the events can be drawn as a curve when charted against time (Curtis P. Schreiber, 2005). We will write a custom essay sample on Why Migraines Occur specifically for you for only $16.38 $13.9/page Order now We will write a custom essay sample on Why Migraines Occur specifically for you FOR ONLY $16.38 $13.9/page Hire Writer We will write a custom essay sample on Why Migraines Occur specifically for you FOR ONLY $16.38 $13.9/page Hire Writer Body Migraine is a chronic medical disorder characterized by disabling headache, nausea, vomiting and photophobia.   In many people, the throbbing headache may be experienced on one-side of the face. The condition usually occurs in 11 % of the people in the US.   Migraine is more common in people with a family risk of the condition. It occurs anywhere between the ages of 10 to 46 years, and is more common in women compared to men.   In women, the condition may even occur beyond till the age of 55 years.   During the period of pregnancy, the number of migranous attacks usually reduces.   During the 1980’s scientists found that migraine develop due to a disorder in the blood vessels that supply the brain.   However, today it is clear that the condition develops due changes in the brain, nerve pathways and the chemicals present in the brain (Dodick, 2008, Kantor, 2006). From one individual to another, the frequency, duration, severity and aggravating factors of migraine would differ significantly.   On an average, people suffer from migraine, one or two days every month.   About 10 % of the population gets the disorder every week and 20 % get the attacks every 2 to 3 days, and about 14 % develop a serious version of the disease, in which the symptoms are seen every alternate day (Dodick, 2008, Kantor, 2006). Several events may trigger or aggravate attacks of migraine including alcohol consumption, dehydration, physical stress, exertion, menstruation, emotional stress, anxiety, seasonal, climatic or weather changes, allergy, bright lights, loud noises, florescent lights, sleep alterations, missing meals, tension headache, use of birth control pills, lack of sleep, staying at higher altitudes, hunger, certain foods, smoking, tobacco consumption, etc.   Some of the foods that can trigger migraine attacks include foods containing tyramine, monosodium glutamate or nitrates. Some of the foods that contain tyramine include red wine, cheese, smoked fish, liver of chicken, bens, figs, etc, and foods that contain nitrate include hot dogs, salami and bacon.   Other foods that can also trigger migraine attacks include citrus fruits, bananas, avocados, onions, dairy products, chocolates, pickles, nuts, peanut butter, fermented products, etc.   The ancient Greeks were the ones to coin the word m igraine from ‘megrim’ meaning hemicrania or one-sided headache.   Galen considered migraine to be a painful disorder that affected one half of the head.   The Greeks considered to be caused due to descent of the vapors from the liver to the brain.   Later, in the 17th century, blood flow defects were considered to be the main cause for migraine rather than humors.   From the 17th century to the 1980’s, the vascular theory proved to be responsible cause for migraine.   Wolff from the Presbyterian hospital New York considered that migraine was caused due to dilatation and expansion of the blood vessels present in the brain.   Once the expansion of the blood vessels occurs, the pain-signaling neurons of the brain get activated, leading to a headache.   Before the headache actually occurs, there is a drop in the blood supply to the brain causing constriction of the blood vessels.   However, newer research work conducted in the field of migraine demons trates that the disorder is caused not due to vascular alterations but due to neurological changes.   Earlier it was thought that vascular flow of the blood in the brain had increased something like 3-fold times.   In fact, latest scientific evidence clearly suggests that just before the migraine attack, the cerebral blood flow is either normal or drops down a bit (Dodick, 2008, Kantor, 2006). The aura that occurs before the migraine attacks was a serious clue to the scientists that the disorder had a neurological basis.   The aura can be seen in two conditions, one in migraine as a preceding symptom and the other in epileptic seizures as a part of the sensory visual hallucinations.   The individual in migraine would be able to see stars, bright lights, sparks, lightning bolts, geometric designs, etc.   In some people weakness, speech impairments and tingling sensations develop.   In some people, the visual aura may not appear and all, but in other it may even occur during the entire headache phase.   Today, scientists have identified the exact mechanism of this aura.   A wave of intense nerve activity (cortical spreading depression) spreads throughout the cortex especially the areas of vision.   Following the hyperexcitability, there is a phase of neural inhibition.   During the phase of intense neuronal activity, there is active firing and a lot of energy is required.   Following the intense neuronal firing, the nerve cells require less quantity of blood.   The neuronal firing spreads at the rate of 2 to 3 millimeters every minute, and this is just the exact rate at which aura develops.   Besides affecting vision, the intense neuronal activity would also affect sensory and motor signals (Dodick, 2008 NINDS, 2008). Studies have clearly shown that genetic factors play a very important role in the development of migraine.   The genetic susceptibility of migraine is similar to other disorders such as diabetes, hypertension, etc.   In identical twins, the other twin is at a higher risk of developing the disorder, when one twin actually suffers from it.   However, non-genetic or environmental factors play an important role in the development of migraine.   Genetic factors may increase the excitability of the neurons, leading to a disturbance in the ion transportation system.   Several other disorders may also be as a cause of ion transportation defects including seizures and cardiac arrhythmias (Dodick, 2008 NINDS, 2008). The exact way in which the spreading cortical depression of neurons causes’ headache is not understood clearly, but scientists feel that the trigeminal nerve may be involved.   The manner in which the trigeminal nerve causes pain sensation is not understood clearly.   When the intense cortical depression spreads, it causes chemical changes in the neurotransmitters leading the trigeminal nerve to transmit pain sensations.   The spreading depression can also activate the trigeminal nerves in the subcortical regions leading to headache.   The mechanism of aura may operate in both, people suffering from migraine with or without aura.   However, in people who do not suffer from aura may develop other symptoms including tiredness, weakness or difficulty concentrating.   Besides, involvement of the cortical and the subcortical regions in migraine, the brain stem (an ancient part of the brain) may be responsible for migraine pain.   The brain stem contains three groups o f nuclei that can play an important role in migraine.   The nuclei would inhibit the firing of the trigeminal nerve, thus causing the trigeminal neuron to fire without any pain signal.   There would be an incoming pain signal although actually there are no stimuli.   Besides, involvement of the trigeminal nerve from the brain stem, other sensory nerves including those that control visual functions may also be affected, resulting in false sensory incoming signals causing visual field disturbances (Dodick, 2008 NINDS, 2008). During an attack of migraine several processes tend to occur.   Certain triggering factors mentioned may stimulate the release of peptides such as substance P, Calcitonin Gene-related peptide, etc.  Ã‚   They tend to dilate blood vessels and cause inflammation which results in over-excitation of the trigeminal nerve.   The brain would not be affected with the headache, but the blood vessels and the meninges would be involved.   Auras occur as a result of blood flow changes (Daniel Kantor, 2007). Certain migraine headaches occur due to abnormalities in the calcium channels and also the magnesium, potassium and sodium channels.   Calcium channels present control the release of the neurotransmitter serotonin.   This neurotransmitter can play an important role in the development of migraine.   Besides, abnormalities in the levels of other neurotransmitters such as dopamine and stress hormones can result in migraine.   Dopamine could act as a stimulant of migraine and in certain individuals with genetic characteristics, higher levels of dopamine can result in nerve cell excitation.   Several prodromal symptoms such as mood changes, drowsiness and yawning are closely associated with dopamine disturbances.   The calcium channels play a vital role in the development of the cortical spreading depression (which is the cause of the migraine symptoms).   In people who suffer from migraine, magnesium deficiencies have been found.   During a migraine attack, a drop in the magnesium levels has been observed.   Once the levels of magnesium levels are low, the nerve cells become highly unstable and tend to misfire.   This could be responsible for the aura that develops.   Magnesium has been strongly associated with the calcium channels in the body.   Certain inherent deficiencies in the calcium channel systems may be present in people who develop migraine. Individuals with familial hemiplegic migraine have mutation of the gene that expresses for calcium channel systems.   Nitric Oxide has also been associated with migraine and other headaches.   Over-excitation of the nerve cells can result in the production of nitric oxide.   A rise in the nitric oxide in the blood vessels may stimulate several nerves in the brain and cause the development of pain.   Hormone fluctuations can also play a role in the development of migraine.   The changes in several hormones especially estrogen can be responsible for migraine development.   If the hor mone levels are high, low or normal for long, the migraine process would not be activated.   Hormonal fluctuations are more likely to cause migraine.   This is because fluctuations impact the serotonin and other neurotransmitter levels (Daniel Kantor, 2007). Conclusion Today, a lot of research has been identified which potentially helps to better under the migraine process.   Migraine is more of a neuro-vascular condition rather than a vascular condition earlier thought.   Currently, there are no specific drugs to treat migraine, and most of them are other groups of drugs that are utilized to treat other conditions.   Usually, ergotamine preparations, painkillers, NSAIDS, etc are given which works partially.   Hence, it has been clearly observed that they can work only in half the number of migraine patients.   Several groups of antihypertensive drugs, anti-seizure drugs, calcium channel blockers and antidepressants may work by normalizing the membrane potential thus helping to curb the rapidly-spreading cortical nerve depression.   They would work in patients who develop migraine with or without aura.   These groups of drugs would work by prevent channels present on the nerve membrane from opening up, thus helping to control calcium movement.   In this way, the nerve membrane would be stabilized.   Individuals also need to adopt a diet that can effectively help avoiding headache provoking foods and substances such as cheese, tobacco, alcohol, etc.   Blood glucose and blood pressure should be monitored and kept under control.   Better sleep hygiene and exercising patterns need to be ensured.   Stress needs to be handled in more appropriate fashions (Curtis P. Schreiber, 2005, Dodick, 2008 Mayo, 2007). Works Cited Curtis P. Schreiber. â€Å"The Pathophysiology of Migraine.† Clinics in Family Practice 7.3 (2005). Daniel Kantoor. â€Å"Migraine headaches – Highlights, FDA Warning: Serotonin Syndrome.† 2007. ADAM. 29 Nov 2008. http://www.mdconsult.com/das/patient/body/111946799-8/777861931/10041/9399.html Daniel Kantor. â€Å"Migraine.† Medical Encyclopedia. 2006. Medline Plus. 16 Nov 2008. http://www.nlm.nih.gov/medlineplus/ency/article/000709.htm David W. Dodick and J. Jay Gargus . â€Å"Why Migraines Strike.† Scientific American. (July, 2008). http://www.sciam.com/article.cfm?id=why-migraines-strike Mayo Clinic. â€Å"Migraine.† 2007. Mayo Clinic. 16 Nov 2008. http://www.mayoclinic.com/print/migraine-headache/DS00120/DSECTION=allMETHOD=print NINDS. â€Å"Headache: Hope through Research.† 2008. NINDS. 16 Nov 2008. http://www.ninds.nih.gov/disorders/headache/detail_headache.htm